Pediatr Infect Dis J. 2009 Oct;28(10):916-8.

Long-term immunogenicity of two pediatric doses of combined hepatitis A and B or monovalent hepatitis B vaccine in 8 to 10-year-old children and the effect of a challenge dose given seven years later.

Gilca V, Dionne M, Boulianne N, Murphy D, De Serres G.

Source

Quebec National Public Health Institute, Quebec, Canada. vladimir.gilca@ssss.gouv.qc.ca

Abstract

A total of 465 children aged 8 to 10 years were vaccinated with 2 doses of Recombivax-HB 2.5 microg (RB) or Twinrix-Junior 10 microg/360 EL.U (TX), according to a 0 and 6 months schedule. Seven years postsecond dose, a challenge dose of vaccine was given. All vaccinees in the TX and 98% in the RB group showed an anamnestic response. Vaccination at the age of 8 to 10 years with two-pediatric doses of TX or RB given with a 6 months interval induces a long-lasting immunity in most vaccinees.

PMID:: 19672212; [PubMed - indexed for MEDLINE]

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