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Expert Rev Pharmacoecon Outcomes Res. 2009 Aug;9(4):347-52. doi: 10.1586/erp.09.32.

Pain management and quality of life in sickle cell disease.

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  • 1Department of Haematology, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, UK.


Sickle cell disease (SCD) is the most common inherited disease worldwide and is responsible for a massive health burden. Its main clinical feature is severe pain that is unpredictable and recurrent, and this, in addition to the other acute and chronic features of SCD, may have a huge impact on the quality of life of both the patient and their families and carers. We consider medical and psychological methods of pain management in SCD, drawing on recently published UK Standards of Care, and also consider the effect of SCD on quality of life.

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