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Cytokine. 2009 Oct-Nov;48(1-2):144-7. doi: 10.1016/j.cyto.2009.07.007. Epub 2009 Aug 8.

T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.

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  • 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.


Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1]. The TRUC (T-bet-/- RAG2-/- ulcerative colitis) model is discussed in the broader context of the adaptive and innate immune mechanisms that regulate host-commensal relationships within the intestine.

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