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    Neuroreport. 1990 Nov-Dec;1(3-4):253-4.

    Normal densities of 5-HT3 receptor recognition sites in Alzheimer's disease.

    Barnes NM, Costall B, Naylor RJ, Williams TJ, Wischik CM.

    Source

    Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire.

    Abstract

    The present studies investigate the possible difference in 5-HT3 receptor recognition site density in amygdaloid and hippocampal homogenates from patients with Alzheimer's disease compared with age-matched controls. The 5-HT3 receptor recognition site radioligand [3H]-(S)-zacopride identified a comparable density of specific sites (defined by granisetron 10.0 microM) in tissues obtained from patients with Alzheimer's disease as compared to age-matched controls (amygdala, Bmax 41 +/- 4 and 43 +/- 9; hippocampus, Bmax 59 +/- 9 and 51 +/- 9 fmol mg-3 protein; tissue from Alzheimer's disease patients and age-matched controls, respectively, mean +/- s.e.m., n = 7-8). These results suggest that the density of 5-HT3 receptor recognition sites labelled by [3H]-(S)-zacopride are not altered in the amygdala and hippocampus of patients with Alzheimer's disease.

    PMID:
    1966609
    [PubMed - indexed for MEDLINE]

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