J Am Acad Dermatol. 2010 Feb;62(2):315-8. Epub 2009 Aug 8.

Minocycline-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome with persistent myocarditis.

Shaughnessy KK, Bouchard SM, Mohr MR, Herre JM, Salkey KS.

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Department of Dermatology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare serious adverse effect associated with a variety of medications. We present a case of minocycline-induced DRESS syndrome, which resulted in acute renal failure, transient thyroiditis, and transaminitis, and a persistent lymphocytic myocarditis resulting in congestive heart failure. To our knowledge, this is the third reported case of minocycline-induced myocarditis. Additionally, we report successful plasmapheresis and rituximab treatment for minocycline-induced myocarditis associated with the DRESS syndrome.

PMID:: 19665822; [PubMed - indexed for MEDLINE]

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