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    Bioorg Med Chem. 2009 Sep 1;17(17):6292-300. Epub 2009 Jul 26.

    Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates.

    LaBeaume P, Wager K, Falcone D, Li J, Torchilin V, Castro C, Holewa C, Kallmerten AE, Jones GB.

    Source

    Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States.

    Abstract

    Methodology is outlined for the chemical synthesis of versatile photo-Bergman enediyne building blocks and their conjugates. Routes to both mono and bis conjugated enediyne templates are detailed together with representative examples of their bioconjugates, nanoconjugates, PEG derivatives and water soluble salts. The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced.

    PMID:
    19665388
    [PubMed - indexed for MEDLINE]

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