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Cell Host Microbe. 2009 Sep 17;6(3):207-17. doi: 10.1016/j.chom.2009.07.006. Epub 2009 Aug 6.

Gene expression signatures diagnose influenza and other symptomatic respiratory viral infections in humans.

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  • 1Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Duke University, Durham, NC 27710, USA.

Abstract

Acute respiratory infections (ARIs) are a common reason for seeking medical attention, and the threat of pandemic influenza will likely add to these numbers. Using human viral challenge studies with live rhinovirus, respiratory syncytial virus, and influenza A, we developed peripheral blood gene expression signatures that distinguish individuals with symptomatic ARIs from uninfected individuals with >95% accuracy. We validated this "acute respiratory viral" signature-encompassing genes with a known role in host defense against viral infections-across each viral challenge. We also validated the signature in an independently acquired data set for influenza A and classified infected individuals from healthy controls with 100% accuracy. In the same data set, we could also distinguish viral from bacterial ARIs (93% accuracy). These results demonstrate that ARIs induce changes in human peripheral blood gene expression that can be used to diagnose a viral etiology of respiratory infection and triage symptomatic individuals.

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PMID:
19664979
[PubMed - indexed for MEDLINE]
PMCID:
PMC2852511
Free PMC Article
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