Psychoneuroendocrinology. 1990;15(5-6):489-93.

Double-blind randomized crossover trial of luteal phase estrogens (Premarin) in the premenstrual syndrome (PMS).

Source

Reproductive Physiology Unit, Montreal General Hospital, Canada.

Abstract

Eleven patients with moderate to severe premenstrual syndrome were given Premarin during the latter half of the menstrual cycle for at least two cycles, and a placebo for at least two cycles. Mental and physical symptoms were monitored daily with a self-rating scale. Premarin was significantly less effective than placebo in relieving the severity of both mental (p less than 0.02) and physical (p less than 0.02) symptoms of PMS (combined data p less than 0.01). It is concluded that luteal phase Premarin is ineffective as a treatment for PMS, and may actually aggravate the symptoms.

PMID:: 1966304; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Estrogens, Conjugated (USP)

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Medical

Premenstrual Syndrome - MedlinePlus Health Information

Molecular Biology Databases

ESTROGENIC SUBSTANCES, CONJUGATED - HSDB

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