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Biomark Insights. 2007 Feb 14;2:45-58.

Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field.

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  • 1Laboratory of Molecular and Cellular Neuroscience, Department of Neuroscience, Karolinska Institute, Retzius väg 8, 17177, Stockholm, Sweden.


Trophic factors control cellular physiology by activating specific receptor tyrosine kinases (RTKs). While the over activation of RTK signaling pathways is associated with cell growth and cancer, recent findings support the concept that impaired down-regulation or deactivation of RTKs may also be a mechanism involved in tumor formation. Under this perspective, the molecular determinants of RTK signaling inhibition may act as tumor-suppressor genes and have a potential role as tumor markers to monitor and predict disease progression. Here, we review the current understanding of the physiological mechanisms that attenuate RTK signaling and discuss evidence that implicates deregulation of these events in cancer.


Receptor tyrosine kinases (RTKs); Trophic factors; negative control and cancer; signal transduction

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