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Biosci Biotechnol Biochem. 2009 Aug;73(8):1908-10. Epub 2009 Aug 7.

Endoplasmic reticulum (ER) stress-suppressive compounds from scrap cultivation beds of the mushroom Hericium erinaceum.

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  • 1Graduate School of Science and Technology, Shizuoka University, Japan.


Four compounds were isolated from scrap cultivation beds of the mushroom, Hericium erinaceum. Compounds 1-4 were identified as methyl 4-hydroxy-3-(3-methylbutanoyl) benzoate, 2-chloro-1,3-dimethoxy-5-methylbenzene, methyl 4-chloro-3,5-dimethoxybenzoate, and 4-chloro-3,5-dimethoxybenzaldehyde by an interpretation of the NMR and MS data, respectively. This is the first reported isolation of 1 from a natural source. All the compounds showed protective activity against endoplasmic reticulum stress-dependent cell death.

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