Omega-3 polyunsaturated fatty acids and cardiovascular diseases

J Am Coll Cardiol. 2009 Aug 11;54(7):585-94. doi: 10.1016/j.jacc.2009.02.084.

Abstract

Omega-3 polyunsaturated fatty acid (omega-3 PUFA) therapy continues to show great promise in primary and, particularly in secondary prevention of cardiovascular (CV) diseases. The most compelling evidence for CV benefits of omega-3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after myocardial infarction, and most recently, with heart failure (HF). We discuss the evidence from retrospective epidemiologic studies and from large randomized controlled trials showing the benefits of omega-3 PUFA, specifically EPA and DHA, in primary and secondary CV prevention and provide insight into potential mechanisms of these observed benefits. The target EPA + DHA consumption should be at least 500 mg/day for individuals without underlying overt CV disease and at least 800 to 1,000 mg/day for individuals with known coronary heart disease and HF. Further studies are needed to determine optimal dosing and the relative ratio of DHA and EPA omega-3 PUFA that provides maximal cardioprotection in those at risk of CV disease as well in the treatment of atherosclerotic, arrhythmic, and primary myocardial disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / drug therapy
  • Atherosclerosis / drug therapy
  • Cardiomyopathies / drug therapy
  • Cardiovascular Diseases / mortality
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / prevention & control*
  • Coronary Disease / prevention & control
  • Diet
  • Docosahexaenoic Acids / administration & dosage
  • Docosahexaenoic Acids / therapeutic use
  • Eicosapentaenoic Acid / administration & dosage
  • Eicosapentaenoic Acid / therapeutic use
  • Fatty Acids, Omega-3 / administration & dosage
  • Fatty Acids, Omega-3 / therapeutic use*
  • Fish Oils / administration & dosage
  • Fishes
  • Heart Conduction System / drug effects
  • Heart Conduction System / physiopathology
  • Heart Failure / mortality
  • Heart Failure / prevention & control
  • Humans
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Seafood / analysis
  • Secondary Prevention*

Substances

  • Fatty Acids, Omega-3
  • Fish Oils
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid