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    FEBS Lett. 2009 Sep 3;583(17):2911-6. Epub 2009 Aug 4.

    N9L and L9N mutations toggle Hha binding and hemolysin regulation by Escherichia coli and Vibrio cholerae H-NS.

    García J, Madrid C, Cendra M, Juárez A, Pons M.

    Source

    Institute for Research in Biomedicine, Parc Científic de Barcelona, Barcelona, Spain.

    Abstract

    Proteins of the Hha/YmoA family co-regulate with H-NS the expression of virulence factors in Enterobacteriaceae. Vibrio cholerae lacks Hha-like proteins and its H-NS (vcH-NS) is unable to bind Hha, in spite of the conservation of a key residue for Hha binding by Escherichia coli H-NS (ecH-NS). Exchange of the residues in position 9 between vcH-NS and ecH-NS strongly reduces Hha binding by ecH-NS and introduces it in vcH-NS. These mutations strongly affect the repression of the hemolysin operon in E. coli and the electrophoretic mobility of complexes formed with a DNA fragment containing its regulatory region.

    PMID:
    19660457
    [PubMed - indexed for MEDLINE]

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