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BMC Proc. 2009 Aug 4;3 Suppl 6:S3. doi: 10.1186/1753-6561-3-S6-S3.

Composition and biological significance of the human Nalpha-terminal acetyltransferases.

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  • 1Department of Molecular Biology, University of Bergen, N-5020 Bergen, Norway. Kristian.Starheim@mbi.uib.no

Abstract

Protein Nalpha-terminal acetylation is one of the most common protein modifications in eukaryotic cells, occurring on approximately 80% of soluble human proteins. An increasing number of studies links Nalpha-terminal acetylation to cell differentiation, cell cycle, cell survival, and cancer. Thus, Nalpha-terminal acetylation is an essential modification for normal cell function in humans. Still, little is known about the functional role of Nalpha-terminal acetylation. Recently, the three major human N-acetyltransferase complexes, hNatA, hNatB and hNatC, were identified and characterized. We here summarize the identified N-terminal acetyltransferase complexes in humans, and we review the biological studies on Nalpha-terminal acetylation in humans and other higher eukaryotes.

PMID:
19660096
[PubMed]
PMCID:
PMC2722096
Free PMC Article
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