Abstract
A 61-year-old man was treated with imiquimod 5% cream for superficial basal cell carcinoma, five times per week for 13 weeks. This resulted in vitiligo-like depigmentation and poliosis in the area of treatment. This rare side-effect has been noted in previous case reports of imiquimod treatment for both genital warts and superficial basal cell carcinoma. This highlights the importance of such a side-effect being discussed with the patient who is to be treated with imiquimod, particularly in cosmetically sensitive areas.
MeSH terms
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Administration, Topical
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Aminoquinolines / adverse effects*
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Aminoquinolines / therapeutic use
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Biopsy, Needle
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Carcinoma, Basal Cell / drug therapy*
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Carcinoma, Basal Cell / pathology
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Follow-Up Studies
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Humans
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Hypopigmentation / chemically induced
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Hypopigmentation / pathology
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Imiquimod
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Immunohistochemistry
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Male
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Middle Aged
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Neoplasm Staging
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Risk Assessment
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Skin Neoplasms / drug therapy*
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Skin Neoplasms / pathology
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Vitiligo / chemically induced*
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Vitiligo / pathology
Substances
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Aminoquinolines
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Antineoplastic Agents
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Imiquimod