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Int J Eat Disord. 2010 Sep;43(6):537-42. doi: 10.1002/eat.20731.

Time course of bone loss in patients with anorexia nervosa.

Author information

  • 1Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain. miromj@humv.es

Abstract

OBJECTIVE:

To evaluate the time course of bone mineral density (BMD) in women with anorexia nervosa (AN) during 2-year follow-up.

METHOD:

We prospectively studied 51 female with AN aged 18-38 years, and 40 age-matched healthy women (19-34 years). BMD was measured in lumbar spine (LS), femoral neck (FN), and total hip (TH) by DXA.

RESULTS:

At baseline, weight, body mass index, and lumbar and hip BMD were significantly (p < .001) lower in AN patients than in controls. Patients who gain weight showed a significant increase in BMD at FN (+1.6%; p < .05), and TH (+4.4%; p < .05) and lower nonsignificant changes in LS (+1.3%). Weight at entry, and percent change of weight were significant determinants (p < .05) of the variability in percent change of BMD at FN and TH, whereas weight at entry was the main determinant of bone modifications at lumbar spine.

DISCUSSION:

Our data emphasize the influence of weight gain in recovery of bone mass in AN patients, especially at the hip.

© 2009 by Wiley Periodicals, Inc.

PMID:
19658172
[PubMed - indexed for MEDLINE]
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