Send to:

Choose Destination
See comment in PubMed Commons below
Int J Eat Disord. 2010 Sep;43(6):537-42. doi: 10.1002/eat.20731.

Time course of bone loss in patients with anorexia nervosa.

Author information

  • 1Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, RETICEF, Santander, Spain.



To evaluate the time course of bone mineral density (BMD) in women with anorexia nervosa (AN) during 2-year follow-up.


We prospectively studied 51 female with AN aged 18-38 years, and 40 age-matched healthy women (19-34 years). BMD was measured in lumbar spine (LS), femoral neck (FN), and total hip (TH) by DXA.


At baseline, weight, body mass index, and lumbar and hip BMD were significantly (p < .001) lower in AN patients than in controls. Patients who gain weight showed a significant increase in BMD at FN (+1.6%; p < .05), and TH (+4.4%; p < .05) and lower nonsignificant changes in LS (+1.3%). Weight at entry, and percent change of weight were significant determinants (p < .05) of the variability in percent change of BMD at FN and TH, whereas weight at entry was the main determinant of bone modifications at lumbar spine.


Our data emphasize the influence of weight gain in recovery of bone mass in AN patients, especially at the hip.

© 2009 by Wiley Periodicals, Inc.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk