Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mol Cells. 2009 Jul 31;28(1):7-12. doi: 10.1007/s10059-009-0111-2. Epub 2009 Jul 20.

Biology of glioma cancer stem cells.

Author information

  • 1University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. parkdm@upmc.edu

Abstract

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

PMID:
19655094
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Publishing M2Community
    Loading ...
    Write to the Help Desk