AIDS Rev. 2009 Jul-Sep;11(3):157-64.

Non-responsiveness to hepatitis B vaccination in HIV seropositive patients; possible causes and solutions.

van den Berg R, van Hoogstraten I, van Agtmael M.

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VU University Medical Center, Amsterdam, The Netherlands.

Abstract

Hyporesponsiveness (anti-HBs 10-100 IU/l) or non-responsiveness (anti-HBs < 10 IU/l) to hepatitis B vaccines is a problem in approximately 20-70% of HIV-positive patients. Mechanisms for impaired humoral and cellular immunity related to the HIV infection are reviewed. Contributing risk factors like age, gender, CD4+ T-cell count, HIV RNA load and coinfection with hepatitis C are highlighted. New developments in improving the HBV vaccine immunogenicity are discussed and clinical recommendations are given for HBV-re-vaccination of HIV patients who failed on standard HBV vaccination.

PMID:: 19654857; [PubMed - indexed for MEDLINE]

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