Display Settings:

Format

Send to:

Choose Destination
Opt Express. 2009 Jul 20;17(15):13157-67.

Analyzing absorption and scattering spectra of micro-scale structures with spectroscopic optical coherence tomography.

Author information

  • 1Biomedical Engineering Department, Northwestern University, 2145 Sheridan Rd., Evanston IL, 60208 USA. ji-yi@northwestern.edu

Abstract

We demonstrate the feasibility of characterizing the absorption and scattering spectra of micron-scale structures in a turbid medium using a spectroscopic optical coherence tomography (SOCT) system with a bandwidth of 430-650 nm. SOCT measurements are taken from phantoms composed of fluorescent microspheres. The absorption and scattering spectra are recovered with proper selections of spatial window width in the post processing step. Furthermore, we present an analysis using numerical OCT simulation based on full-wave solutions of the Maxwell's Equation to elucidate the origination of the multiple peaks in the OCT image for a single microsphere. Finally, we demonstrate the possibility of identifying contrast agents concentrated in micron-sized scale in an SOCT image. Two different types of microspheres in gel phantom are discriminated based on their distinguished absorbent feature.

PMID:
19654721
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Optical Society of America
    Loading ...
    Write to the Help Desk