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Opt Express. 2009 Jul 20;17(15):12571-81.

Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound.

Author information

  • 1Department of Physics and Astronomy, University of Pennsylvania, 209 S. 33rd St, Philadelphia, PA 19104, USA. ebuckle2@sas.upenn.edu

Abstract

Four very low birth weight, very premature infants were monitored during a 12 degrees postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (p(A) =0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p>0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12 degrees ) in these patients.

PMID:
19654660
[PubMed - indexed for MEDLINE]
PMCID:
PMC2723781
Free PMC Article

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