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Br J Cancer. 2009 Sep 1;101(5):813-5. doi: 10.1038/sj.bjc.6605226. Epub 2009 Aug 4.

Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma.

Author information

  • 1Department of Dermatology, University of Tübingen Medical Center, Liebermeisterstr. 25, Tübingen 72076, Germany. mail@j-bauer.de

Abstract

BACKGROUND:

Recently, oncogenic G protein alpha subunit q (GNAQ) mutations have been described in about 50% of uveal melanomas and in the blue nevi of the skin.

METHODS:

GNAQ exon 5 was amplified from 75 ciliary body and choroidal melanoma DNAs and sequenced directly. GNAQ mutation status was correlated with disease-free survival (DFS), as well as other clinical and histopathological factors, and with chromosomal variations detected by FISH and CGH.

RESULTS:

Of the 75 tumour DNA samples analysed, 40 (53.3%) harboured oncogenic mutations in GNAQ codon 209. Univariate and multivariate analysis showed that GNAQ mutation status was not significantly correlated with DFS.

CONCLUSION:

The GNAQ mutation status is not suitable to predict DFS. However, the high frequency of GNAQ mutations may render it a promising target for therapeutic intervention.

PMID:
19654573
[PubMed - indexed for MEDLINE]
PMCID:
PMC2736834
Free PMC Article
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