Send to:

Choose Destination
See comment in PubMed Commons below
Vaccine. 2009 Sep 18;27(41):5562-4. doi: 10.1016/j.vaccine.2009.07.043. Epub 2009 Aug 3.

Too much of a good thing: management of BCG vaccine overdose.

Author information

  • 1Department of Paediatrics, The University of Melbourne, VIC 3052, Australia.


A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk