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Retrovirology. 2009 Aug 3;6:71. doi: 10.1186/1742-4690-6-71.

The HBZ gene, a key player in HTLV-1 pathogenesis.

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  • 1Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan.


Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ) gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.

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