Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Microbiol. 2009 Sep;7(9):623-8. doi: 10.1038/nrmicro2171. Epub 2009 Aug 3.

Listeria monocytogenes - from saprophyte to intracellular pathogen.

Author information

  • 1Department of Microbiology and Immunology (MC790), University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 606127344, USA. nfreitag@uic.edu

Abstract

Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we describe the regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage.

PMID:
19648949
[PubMed - indexed for MEDLINE]
PMCID:
PMC2813567
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk