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Homeopathy. 2009 Jul;98(3):137-41. doi: 10.1016/j.homp.2009.05.006.

Homeopathic treatment of minor aphthous ulcer: a randomized, placebo-controlled clinical trial.

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  • 1Department of Oral Medicine, Tehran University of Medical Sciences, Dental School, Tehran, Iran.



The objectives of this study were to clinically determine the efficacy of individualised homeopathy in the treatment of minor recurrent aphthous ulceration (MiRAU).


A randomized, single blind, placebo-controlled clinical trial of individualised homeopathy. One hundred patients with minor aphthous ulcer were treated with individualised homeopathic medicines or placebo and followed up for 6 days. Patients received two doses of individualised homeopathic medicines in the 6C potency as oral liquid at baseline and 12 h later. Pain intensity and ulcer size were recorded at baseline during and at the end of the trial (mornings of days 4 and 6).


All 100 patients completed treatment. Between group differences for pain intensity and ulcer size were statistically significant at day 4 and at day 6 (P<0.05). No adverse effects were reported.


The results suggest that homeopathic treatment is an effective and safe method in the treatment of MiRAU.

[PubMed - indexed for MEDLINE]
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