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Clin Neurophysiol. 2009 Sep;120(9):1667-82. doi: 10.1016/j.clinph.2009.06.020. Epub 2009 Jul 30.

Spatio-temporal EEG waves in first episode schizophrenia.

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  • 1Laboratory for Perceptual Dynamics, RIKEN Brain Science Institute, Japan. dalex@brain.riken.jp

Abstract

OBJECTIVE:

Schizophrenia is characterized by a deficit in context processing, with physiological correlates of hypofrontality and reduced amplitude P3b event-related potentials. We hypothesized an additional physiological correlate: differences in the spatio-temporal dynamics of cortical activity along the anterior-posterior axis of the scalp.

METHODS:

This study assessed latency topographies of spatio-temporal waves under task conditions that elicit the P3b. EEG was recorded during separate auditory and visual tasks. Event-related spatio-temporal waves were quantified from scalp EEG of subjects with first episode schizophrenia (FES) and matched controls.

RESULTS:

The P3b-related task conditions elicited a peak in spatio-temporal waves in the delta band at a similar latency to the P3b event-related potential. Subjects with FES had fewer episodes of anterior to posterior waves in the 2-4 Hz band compared to controls. Within the FES group, a tendency for fewer episodes of anterior to posterior waves was associated with high Psychomotor Poverty symptom factor scores.

CONCLUSIONS:

Subjects with FES had altered global EEG dynamics along the anterior-posterior axis during task conditions involving context update.

SIGNIFICANCE:

The directional nature of this finding and its association with Psychomotor Poverty suggest this result is related to findings of hypofrontality in schizophrenia.

[PubMed - indexed for MEDLINE]
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