Curr Opin Immunol. 2009 Aug;21(4):378-84. Epub 2009 Jul 29.

T cells in mycobacterial infection and disease.

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The Trudeau Institute, Inc., Saranac Lake, NY 12983, USA. acooper@trudeauinstitute.org

Abstract

There has been an increase in our understanding of the complexity of the T cell response to mycobacterial infection recently. Improved tools have allowed the determination of the location and kinetics of naïve T cell activation in the mouse as well the variety of function of mycobacteria-specific cells in humans. There is also an increased appreciation of the balance required during mycobacterial infection between anti-bacterial activity and control of the immunopathologic response. The integration of the T cell functional data with the consequences of infection should improve rational vaccine design.

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