Thromb Res Suppl. 1990;12:87-90.

Dipyridamole potentiates the anti-aggregating effect of endothelium-derived relaxing factor.

Sakuma I, Akaishi Y, Fukao M, Makita Y, Makita MA, Kobayashi T, Matsuno K, Miyazaki T, Yasuda H.

Source

Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo, Japan.

Abstract

One effector of the anti-aggregatory property of endothelium is thought to be endothelium-derived relaxing factor. The best characterized of these, nitric oxide, inhibits platelet aggregation by increasing cyclic GMP levels. The effects of nitric oxide and dipyridamole (a cyclic GMP phosphodiesterase inhibitor), alone and in combination, on in vitro platelet aggregation were evaluated. Dipyridamole had no effect per se on platelet aggregation but potentiated the inhibition of aggregation due to nitric oxide. This was concomitant with an increase in platelet cyclic GMP concentration. The author suggests an alternative mechanism for the clinical efficacy of dipyridamole as an antiplatelet agent.

PMID:: 1964511; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

In Vitro

MeSH Terms

Substances

LinkOut - more resources

Medical

Blood Thinners - MedlinePlus Health Information

Molecular Biology Databases

NITRIC OXIDE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Dipyridamole potentiates platelet inhibition by nitric oxide. [Thromb Haemost. 1991]
Dipyridamole potentiates platelet inhibition by nitric oxide.
Bult H, Fret HR, Jordaens FH, Herman AG. Thromb Haemost. 1991 Sep 2; 66(3):343-9.
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. [Br J Pharmacol. 1995]
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase.
Wu CC, Ko FN, Kuo SC, Lee FY, Teng CM. Br J Pharmacol. 1995 Oct; 116(3):1973-8.
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. [Circ Res. 1989]
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.
Stamler J, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J. Circ Res. 1989 Sep; 65(3):789-95.
Review Antiplatelet effects of endothelium-derived relaxing factor and nitric oxide donors. [Eur Heart J. 1991]
Review Antiplatelet effects of endothelium-derived relaxing factor and nitric oxide donors.
Bassenge E. Eur Heart J. 1991 Nov; 12 Suppl E:12-5.
Review Translational therapeutics of dipyridamole. [Arterioscler Thromb Vasc Biol....]
Review Translational therapeutics of dipyridamole.
Kim HH, Liao JK. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):s39-42. Epub 2008 Jan 3.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Dipyridamole potentiates the anti-aggregating effect of endothelium-derived rela...
Dipyridamole potentiates the anti-aggregating effect of endothelium-derived relaxing factor.
Thromb Res Suppl. 1990 ;12:87-90.

PubMed
Telaprevir for chronic HCV infection.
Telaprevir for chronic HCV infection.
N Engl J Med. 2009 Jul 30 ;361(5):534; author reply 534-5.

PubMed
Atypical antipsychotic use and risk of fracture in persons with Parkinsonism.
Atypical antipsychotic use and risk of fracture in persons with Parkinsonism.
Mov Disord. 2009 Oct 15 ;24(13):1941-8.

PubMed
Age-specific physical activity and prostate cancer risk among white men and blac...
Age-specific physical activity and prostate cancer risk among white men and black men.
Cancer. 2009 Nov 1 ;115(21):5060-70.

PubMed
In vitro propagation and characterization of neoplastic stem/progenitor-like cel...
In vitro propagation and characterization of neoplastic stem/progenitor-like cells from human prostate cancer tissue.
Prostate. 2009 Nov 1 ;69(15):1683-93.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: