Cell Death Differ. 2010 Feb;17(2):200-8. Epub 2009 Jul 31.

MicroRNAs as regulators of death receptors signaling.

Garofalo M, Condorelli GL, Croce CM, Condorelli G.

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Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.

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Cell Death Differ. 2010 May;17(5):900.

Abstract

Death receptors, belonging to the TNF receptor superfamily, induce apoptosis through two different pathways, one involving the effector caspases directly (type I cells or mitochondria-independent death), the other one amplifying the death signal through the mitochondrial pathway (type II cells or mitochondria-dependent death). MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate the stability or translational efficiency of targeted messenger RNAs. MiRNAs are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. In this review we will discuss recent findings implicating miRNAs as regulators of death receptors and pro- and antiapoptotic genes involved in programmed cell death pathways.

PMID:: 19644509; [PubMed - indexed for MEDLINE]

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