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    Dev Pharmacol Ther. 1990;15(2):86-93.

    Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis.

    Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N.

    Source

    Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, N.Y.

    Abstract

    Sodium bicarbonate (BC) and dichloroacetate (DCA) were studied in 7- to 14-day-old (n = 25) anesthetized swine with hypoxic acidosis. BC (base deficit X kg X 0.3, n = 10), DCA (300 mg/kg, n = 7) or saline (n = 8) was infused for 1 h. Blood lactic acid, dP/dtmax, heart rate and cardiac output increased and base excess and total arterial and carotid resistances (R) decreased with acidosis; aortic pressure, renal and mesenteric R did not change. BC induced higher pH, base excess and lactic acid. Heart rate in all and dP/dtmax with BC and DCA were restored; renal and mesenteric R and aortic pressure decreased in all. Cardiovascular responses to DCA and BC did not differ except for renal R. Conclusion: BC is a more effective alkalizer than DCA, which induced a greater renal vasodilation; both restored contractility.

    PMID:
    1964114
    [PubMed - indexed for MEDLINE]

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