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Curr Biol. 2009 Jul 28;19(14):R558-61. doi: 10.1016/j.cub.2009.06.017.

Limb development: the rise and fall of retinoic acid.

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  • 1Cancer and Developmental Biology Laboratory, National Cancer Institute, NCI-Frederick, Frederick, MD 21702, USA.


Retinoic acid was thought to play a key instructive role during limb bud initiation and subsequent patterning. New results argue instead that its role is permissive: retinoic acid is essential only to antagonize early axial Fgf signals that otherwise inhibit the limb field.

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