Curr Diab Rep. 2009 Aug;9(4):287-90.

The use of oral antidiabetic medications in gestational diabetes mellitus.

Source

Warren Alpert School of Medicine of Brown University/Women and Infants Hospital, Providence, RI 02905, USA. mpaglia@wihri.org

Abstract

Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance with onset or first recognition during pregnancy. When medical nutrition therapy is not successful in maintaining target glucose values during pregnancy complicated by GDM, medication is required. Insulin has been the traditional treatment under such circumstances. The use of oral antidiabetic medications in the management of gestational diabetes has increased over the past several years. Recent studies have shown the equivalence to insulin of both glyburide and metformin in terms of pregnancy outcomes in GDM. However, both agents have been shown to cross the placenta to the fetus, and thus they should be used with caution and patients counseled appropriately.

PMID:: 19640341; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

METFORMIN HYDROCHLORIDE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review Is there a role for oral antihyperglycemics in gestational diabetes and type 2 diabetes during pregnancy? [Treat Endocrinol. 2004]
Review Is there a role for oral antihyperglycemics in gestational diabetes and type 2 diabetes during pregnancy?
Homko CJ, Sivan E, Reece AE. Treat Endocrinol. 2004; 3(3):133-9.
Review Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review. [Obstet Gynecol. 2009]
Review Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review.
Nicholson W, Bolen S, Witkop CT, Neale D, Wilson L, Bass E. Obstet Gynecol. 2009 Jan; 113(1):193-205.
Review Oral hypoglycemic agents for gestational diabetes mellitus? [Expert Opin Drug Saf. 2011]
Review Oral hypoglycemic agents for gestational diabetes mellitus?
Maymone AC, Baillargeon JP, Ménard J, Ardilouze JL. Expert Opin Drug Saf. 2011 Mar; 10(2):227-38. Epub 2011 Jan 6.
[Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic]. [Ned Tijdschr Geneeskd. 2009]
[Oral blood glucose-lowering medication as a monotherapy in gestational diabetes: a hotly debated topic].
de Valk HW. Ned Tijdschr Geneeskd. 2009; 153:A330.
Review Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis. [Am J Obstet Gynecol. 2010]
Review Oral hypoglycemic agents vs insulin in management of gestational diabetes: a systematic review and metaanalysis.
Dhulkotia JS, Ola B, Fraser R, Farrell T. Am J Obstet Gynecol. 2010 Nov; 203(5):457.e1-9. Epub 2010 Aug 24.

See reviews... See all...

Cited by 1 PubMed Central article

Gestational diabetes mellitus: maternal and perinatal outcomes in 220 saudi women. [Oman Med J. 2012]
Gestational diabetes mellitus: maternal and perinatal outcomes in 220 saudi women.
Gasim T. Oman Med J. 2012 Mar; 27(2):140-4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The use of oral antidiabetic medications in gestational diabetes mellitus.
The use of oral antidiabetic medications in gestational diabetes mellitus.
Curr Diab Rep. 2009 Aug ;9(4):287-90.

PubMed
Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.
Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.
BMC Cancer. 2009 Jul 29 ;9:258.

PubMed
Comparisons of ice packs, hot water immersion, and analgesia injection for the t...
Comparisons of ice packs, hot water immersion, and analgesia injection for the treatment of centipede envenomations in Taiwan.
Clin Toxicol (Phila). 2009 Aug ;47(7):659-62.

PubMed
Autism: an emerging 'neuroimmune disorder' in search of therapy.
Autism: an emerging 'neuroimmune disorder' in search of therapy.
Expert Opin Pharmacother. 2009 Sep ;10(13):2127-43.

PubMed
Meat consumption and cancer risk: a case-control study in Uruguay.
Meat consumption and cancer risk: a case-control study in Uruguay.
Asian Pac J Cancer Prev. 2009 Jul-Sep ;10(3):429-36.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: