OBJECTIVE: To investigate the association of chronic endometritis (CE) with abnormal uterine bleeding, chronic pelvic pain, human immunodeficiency virus (HIV) infection, genital tract infection and salpingitis. STUDY DESIGN: In this retrospective study, specimens obtained from endometrial biopsy, dilatation and curettage or hysterectomy were identified. A total of 123 patients with CE and 177 without CE who were used as controls were included in the study. RESULTS: The patients with CE were younger than controls (p = 0.0001) and were more likely to be premenopausal (p = 0.0004). There was no association of CE with body mass index (p = 0.82), pelvic pain (p = 0.88) or abnormal uterine bleeding (p = 0.80). None of the specimens with CE had atrophic endometrium (p = 0.0018). CE was significantly associated with history of genital tract infection (p = 0.0032), HIV infection (p = 0.0018) and salpingitis (p = 0.0007). CONCLUSION: There was significant association of CE with historical factors, but not with symptomatology.