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Sci Signal. 2009 Jul 28;2(81):pe47. doi: 10.1126/scisignal.281pe47.

Dynamic advances in NF-kappaB signaling analysis.

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  • 1Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku; Japan Science and Technology Agency, CREST, Kyoto 606-8507, Japan.


Signaling through the transcription factor nuclear factor kappaB (NF-kappaB) regulates various physiological processes, including immune responses and inflammation. An analysis of NF-kappaB dynamics suggests that the oscillation frequency of NF-kappaB activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways.

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