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Clin Cancer Res. 2009 Aug 1;15(15):4787-9. doi: 10.1158/1078-0432.CCR-09-0902. Epub 2009 Jul 28.

Tumor endothelial cells join the resistance.

Author information

  • 1Vascular Biology Program, Departments of Surgery and Pathology, Harvard Medical School, Boston, MA 02115, USA. andrew.dudley@childrens.harvard.edu

Abstract

The field of antiangiogenesis research has been met with some surprises, including the realization that tumor blood vessels are more complex and labile than expected. In this issue of Clinical Cancer Research, Xiong and colleagues show that tumor-specific endothelial cells are less sensitive to cytotoxic and antiangiogenic drugs compared to their normal counterparts.

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PMID:
19638456
[PubMed - indexed for MEDLINE]
PMCID:
PMC2729656
Free PMC Article
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