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J Cell Biol. 2009 Jul 27;186(2):193-200. doi: 10.1083/jcb.200905016.

SUMOylation of nuclear actin.

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  • 1Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.

Abstract

Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport. Nevertheless, the regulation of nuclear actin by posttranslational modifications has not been investigated. We now show that nuclear actin is modified by SUMO2 and SUMO3 and that computational modeling and site-directed mutagenesis identified K68 and K284 as critical sites for SUMOylating actin. We also present a model for the actin-SUMO complex and show that SUMOylation is required for the nuclear localization of actin.

PMID:
19635839
[PubMed - indexed for MEDLINE]
PMCID:
PMC2717643
Free PMC Article
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