The DNR (do-not-resuscitate) order is being increasingly used in pediatric practice. However, all too frequently, the DNR is signed too near the time of death in actual clinical practice. However, even so, the usage of DNR is still deemed inadequate. This article aimed to discuss the dilemma of using DNR in neonatal care. A lack of clear instructions from terminal neonatal patients affects the decision making of physicians. There is also a lack of guidelines for DNR use, which could lead to its lack of completeness. Different cultural and religious backgrounds may affect communication and ethical considerations for neonatal patients. The paper provides some suggestions for the clinical practice of DNR based on a review of the literature. It is hoped that a joint effort between clinical institutions and schools can improve neonatal care quality.