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Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006.

RIP kinases at the crossroads of cell death and survival.

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  • 1Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium.


Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.

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