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Cell. 2009 Jul 23;138(2):220-2. doi: 10.1016/j.cell.2009.07.007.

Cell death: a new Par-4 the TRAIL.

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  • 1Laboratory of Molecular Oncology and Cell Cycle Regulation, Department of Medicine (Hematology/Oncology), University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.


The protein Par-4 acts in the cytoplasm to trigger cell death signaling via caspase activation and the mitochondrial release of cytochrome c. Burikhanov et al. (2009) now provide surprising evidence that Par-4 can also promote apoptosis from outside the cell, after its secretion in response to endoplasmic reticulum stress.

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