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Science. 2009 Jul 24;325(5939):429-32. doi: 10.1126/science.1171347.

Transcriptional regulatory circuits: predicting numbers from alphabets.

Author information

  • 1Howard Hughes Medical Institute, Harvard University Faculty of Arts and Sciences Center for Systems Biology, Department of Molecular and Cellular Biology, Cambridge, MA 02138, USA.

Abstract

Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.

PMID:
19628860
[PubMed - indexed for MEDLINE]
PMCID:
PMC2745280
Free PMC Article

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