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Diabetes Care. 2009 Oct;32(10):1823-5. doi: 10.2337/dc09-0477. Epub 2009 Jul 23.

Associations between dietary fiber and inflammation, hepatic function, and risk of type 2 diabetes in older men: potential mechanisms for the benefits of fiber on diabetes risk.

Author information

  • 1Department of Primary Care and Population Health, University College Medical School, Hampstead Campus, University College London, London, UK. goya@pcps.ucl.ac.uk

Abstract

OBJECTIVE:

To examine the relationship between dietary fiber and the risk of type 2 diabetes in older men and the role of hepatic and inflammatory markers.

RESEARCH DESIGN AND METHODS:

The study was performed prospectively and included 3,428 nondiabetic men (age 60-79 years) followed up for 7 years, during which there were 162 incident cases of type 2 diabetes.

RESULTS:

Low total dietary fiber (lowest quartile < or =20 g/day) was associated with increased risk of diabetes after adjustment for total calorie intake and potential confounders (relative risk -1.47 [95% CI 1.03-2.11]). This increased risk was seen separately for both low cereal and low vegetable fiber intake. Dietary fiber was inversely associated with inflammatory markers (C-reactive protein, interleukin-6) and with tissue plasminogen activator and gamma-glutamyl transferase. Adjustment for these markers attenuated the increased risk (1.28 [0.88-1.86]).

CONCLUSIONS:

Dietary fiber is associated with reduced diabetes risk, which may be partly explained by inflammatory markers and hepatic fat deposition.

Comment in

PMID:
19628814
[PubMed - indexed for MEDLINE]
PMCID:
PMC2752933
Free PMC Article
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