Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pigment Cell Melanoma Res. 2009 Dec;22(6):819-26. doi: 10.1111/j.1755-148X.2009.00609.x. Epub 2009 Jul 21.

Independent regulation of hair and skin color by two G protein-coupled pathways.

Author information

  • 1Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. cvr@interchange.ubc.ca

Abstract

Hair color and skin color are frequently coordinated in mammalian species. To explore this, we have studied mutations in two different G protein coupled pathways, each of which affects the darkness of both hair and skin color. In each mouse mutant (Gnaq(Dsk1), Gna11(Dsk7), and Mc1r(e)), we analyzed the melanocyte density and the concentrations of eumelanin (black pigment) and pheomelanin (yellow pigment) in the hair or skin to determine the mechanisms regulating pigmentation. Surprisingly, we discovered that each mutation affects hair and skin color differently. Furthermore, we have found that in the epidermis, the melanocortin signaling pathway does not couple the synthesis of eumelanin with pheomelanin, as it does in hair follicles. Even by shared signaling pathways, hair and skin melanocytes are regulated quite independently.

PMID:
19627560
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk