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J Forensic Sci. 2009 Sep;54(5):1016-21. doi: 10.1111/j.1556-4029.2009.01105.x. Epub 2009 Jul 15.

Texas population substructure and its impact on estimating the rarity of Y STR haplotypes from DNA evidence*.

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  • 1Department of Forensic and Investigative Genetics, Institute of Investigative Genetics, University of North Texas Health Science Center at Ft Worth, TX 76107, USA. bbudowle@hsc.unt.edu

Abstract

Three sampled populations of unrelated males--African American, Caucasian, and Hispanic, all from Texas-were typed for 16 Y short tandem repeat (STR) markers using the AmpFlSTR Yfiler kit. These samples also were typed previously for the 13 core CODIS autosomal STR loci. Most of the 16 marker haplotypes (2478 out of 2551 distinct haplotypes) were observed only once in the data sets. Haplotype diversities were 99.88%, 99.89%, and 99.87% for the African American, Caucasian, and Hispanic sample populations, respectively. F(ST) values were very small when a haplotype comprised 10-16 markers. This suggests that inclusion of substructure correction is not required. However, haplotypes consisting of fewer loci may require the inclusion of F(ST) corrections. The testing of independence of autosomal and Y STRs supports the proposition that the frequencies of autosomal and Y STR profiles can be combined using the product rule.

PMID:
19627418
[PubMed - indexed for MEDLINE]
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