Med Res Rev. 2010 Jul;30(4):667-707.

Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions.

Source

Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. erik.declercq@rega.kuleuven.be

Abstract

This review article presents the fourth part (part D) in the series of stories on antiviral drug discovery. The stories told in part D focus on: (i) the cyclotriazadisulfonamide compounds; (ii) the {5-[(4-bromophenylmethyl]-2-phenyl-5H-imidazo[4,5-c]pyridine} compounds; (iii) (1H,3H-thiazolo[3,4-a]benzimidazole) derivatives; (iv) T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) and (v) its structurally closely related analogue pyrazine 2-carboxamide (pyrazinamide); (vi) new strategies for the treatment of hemorrhagic fever virus infections, including, as the most imminent, (vii) dengue fever, (viii) the veterinary use of acyclic nucleoside phosphonates; (ix) the potential (off-label) use of cidofovir in the treatment of papillomatosis, particularly RRP (recurrent respiratory papillomatosis); and (x) finally, the prophylactic use of tenofovir to prevent HIV infections.

PMID:: 19626594; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Review The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures. [Med Res Rev. 2011]
Review The next ten stories on antiviral drug discovery (part E): advents, advances, and adventures.
De Clercq E. Med Res Rev. 2011 Jan; 31(1):118-60.
Review Antiviral drug discovery: ten more compounds, and ten more stories (part B). [Med Res Rev. 2009]
Review Antiviral drug discovery: ten more compounds, and ten more stories (part B).
De Clercq E. Med Res Rev. 2009 Jul; 29(4):571-610.
Review The discovery of antiviral agents: ten different compounds, ten different stories. [Med Res Rev. 2008]
Review The discovery of antiviral agents: ten different compounds, ten different stories.
De Clercq E. Med Res Rev. 2008 Nov; 28(6):929-53.
Review Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives. [Med Res Rev. 2009]
Review Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
De Clercq E. Med Res Rev. 2009 Jul; 29(4):611-45.
Review Acyclic nucleoside phosphonates: a key class of antiviral drugs. [Nat Rev Drug Discov. 2005]
Review Acyclic nucleoside phosphonates: a key class of antiviral drugs.
De Clercq E, Holý A. Nat Rev Drug Discov. 2005 Nov; 4(11):928-40.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Yet another ten stories on antiviral drug discovery (part D): paradigms, paradox...
Yet another ten stories on antiviral drug discovery (part D): paradigms, paradoxes, and paraductions.
Med Res Rev. 2010 Jul ;30(4):667-707.

PubMed
Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution a...
Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice.
J Appl Toxicol. 2009 Nov ;29(8):662-72.

PubMed
Pap smear receipt among Vietnamese immigrants: the importance of health care fac...
Pap smear receipt among Vietnamese immigrants: the importance of health care factors.
Ethn Health. 2009 Dec ;14(6):575-89.

PubMed
CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demy...
CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination.
Autoimmunity. 2009 Sep ;42(6):484-91.

PubMed
Predictors of compliance with continuous positive airway pressure treatment in p...
Predictors of compliance with continuous positive airway pressure treatment in patients with obstructive sleep apnea and metabolic syndrome.
Wien Klin Wochenschr. 2009 ;121(11-12):398-404.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: