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Dev Dyn. 2010 Jan;239(1):34-44. doi: 10.1002/dvdy.22019.

Regulation of Wnt/beta-catenin signaling by protein kinases.

Author information

  • 1Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada. everheye@sfu.ca

Abstract

The Wnt/beta-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.

(c) 2009 Wiley-Liss, Inc.

PMID:
19623618
[PubMed - indexed for MEDLINE]
PMCID:
PMC3173947
Free PMC Article

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