Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Health Aff (Millwood). 2009 Sep-Oct;28(5):w794-808. doi: 10.1377/hlthaff.28.5.w794. Epub 2009 Jul 21.

Comparative effectiveness research for antipsychotic medications: how much is enough?

Author information

  • 1University of Chicago, Chicago, Illinois, USA. dmeltzer@medicine.bsd.uchicago.edu

Abstract

Second-generation antipsychotics have attracted practitioners' and policy-makers' attention, because of concerns over their health effects and costs. Comparative effectiveness data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE)-a high-profile National Institutes of Health (NIH)-funded study-have been used to argue for restricting coverage for these costly drugs. But concerns about the design of CATIE and its associated cost-effectiveness analysis and uncertainty about the precision of these findings raise questions about this interpretation. Our work suggests that additional research to increase the precision of comparisons of the effectiveness of antipsychotics would be well worth the cost.

PMID:
19622539
[PubMed - indexed for MEDLINE]
PMCID:
PMC3242475
Free PMC Article

Images from this publication.See all images (3)Free text

EXHIBIT 3
EXHIBIT 4
EXHIBIT 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk