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Pediatr Blood Cancer. 2009 Dec;53(6):1111-3. doi: 10.1002/pbc.22200.

Langerhans cell histiocytosis in a patient with stage 4 neuroblastoma receiving oral fenretinide.

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  • 1Division of Hematology/Oncology, Cincinnati Children's Hospital, Cincinnati, Ohio 45249, USA.


Langerhans cell histiocytosis (LCH) has previously been reported in association with other malignancies. The pathogenesis of LCH and its relationship to other malignancies is poorly understood. We present a novel case of a child who developed an LCH bone lesion while receiving a Phase I protocol therapy with oral fenretinide/Lym-X-Sorb (4-HPR/LXS) powder for neuroblastoma.

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