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    Nat Genet. 2009 Aug;41(8):873-5. Epub 2009 Jul 20.

    Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

    Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L, Iyadurai K, Becker N, Brooks-Wilson A, Curry JD, Spinelli JJ, Holly EA, Riby J, Zhang L, Nieters A, Smith MT, Brown KM.

    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA. chrisfs@berkeley.edu

    We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).

    PMID: 19620980 [PubMed - indexed for MEDLINE]

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