Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am Heart J. 2009 Aug;158(2):193-201.e1-5. doi: 10.1016/j.ahj.2009.06.003.

The expanded Global Registry of Acute Coronary Events: baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes.

Collaborators (708)

Gurfinkel E, Duronto E, Caridi M, Marinesco A, Luna MA, Bruno ML, Torres H, Perez de la Hoz R, Brito V, Beck E, Litvak-Bruno M, Campo A, Maccagno G, Santopinto J, Budassi N, Valle M, Blanca B, Sosa-Liprandi A, Pellegrini C, Mitre S, Brieger D, Aliprandi-Costa B, Brazete S, Brosnan A, Fleming J, Hall J, Heagerty E, McGarity B, Corliss J, Colwell T, Langdon K, Beattie K, Davis P, Donnell J, Waites J, Keays P, Bowen S, Cahill P, Juergens C, Gavigan SA, Pickard K, Lefkovits J, Ruane S, Russell D, Sallaberger M, Brieger D, Aliprandi-Costa B, Miller V, Counsell J, Bogart M, Hempenstall M, Martin C, Martin M, Newman R, Peeler C, Gaul G, Friedrich O, Krankenhaus H, Simader H, Glaser S, Neustadt KW, Harb S, Forenbacher H, Gasser C, Saurer G, Weihs W, Schaflinger E, Lechner P, Schellnegger W, Fressner M, Windisch M, Klein W, Kraxner W, Van de Werf F, De Velder L, Luys C, Coussement P, Decante J, DeRycker K, Rotsaert A, Quiñonez M, Coenen A, Creplet J, Chaumont P, Dubois P, Henuzet C, Renard M, De Clippel M, Develter I, De Raedt H, DeKnijf K, Avezum A, Ramos R, Timerman A, Paulo Pereira M, Marcilio CS, Nakamura RS, Peixoto MS, Laranjeira L, Kaneko R, Coutinho M, Bebetio MG, Marin-Neto J, Pazin-Filho A, Nigro Maia L, Lemos MA, Marino R, Abreu F, Esteves J, Esteves Barbosa C, Ferraz Peixoto MM, Carvalho A, Laet VL, Bertoni J, Rassi A, Albuquerque D, Rocha RM, Goodman S, Zile B, McKie S, Rodrigues M, Wawrzyniak J, Strauss H, Anderson P, Chetty R, Rickeard D, Yakopich M, Bauer R, Parsons J, Bhesania T, Caulfield K, Cha J, Bilich J, Spencer F, Stevens P, Esporlas-Jewer I, Leader R, Harrison C, DeVilla M, Kolodziejczyk B, Vardy C, Gangbar E, Hess A, Benke C, Steg G, Abergel H, Dauphin A, Montalescot G, Gallois V, Vignolles N, Brugier D, Haiat R, Brami M, Kahn JC, Cohen A, Lang S, Guerin C, Philippe F, Guerin C, Gulba D, Klutman M, Schneider B, Wollersheim E, Düren K, Nissen P, Hoffman U, Gross C, Schmidt S, Ohlmeier H, Jander S, Gunold H, Harenberg J, Koch S, Birkenheier H, Ochs G, Haase K, Kulinna W, Behrens S, Thomsen H, Agnelli G, Ambrosio G, Del Pinto M, Casazza F, Bongarzoni A, Bovelli D, Zumbo F, Cuccia C, Biancia F, Guarnerio M, Arcuri G, Capponi E, Maragoni G, Bardelli G, Settimi ME, Gasperini U, Filippucci L, Marinacci L, Monteluce P, Elliott J, Moran S, Scott N, Devlin G, Silverstone A, Budaj A, Flasinska K, Makuch M, Marczyk T, Skiba-Olesniewicz B, Szpajer M, Puzio E, Kawka-Urbanek T, Przywoska-Para B, Krasowski W, Lajkowski Z, Trenkner W, Monies F, Gessek J, Dobrowolski M, López-Sendón J, López de Sa E, Roldan I, Martín-Jadraque L, Worner F, Minano A, Sancho LB, Gomez-Guindal J, Iosa D, Ros J, Rubio R, Gomez de Diego JJ, Fox K, Carruthers K, Flather M, Francis M, Traill J, Jacob A, White E, Fairley K, Starkey I, Bett F, Osborne W, Gore J, Goldberg R, DiBenedetto D, Lopez J, Robuccio L, Kirshenbaum H, George J, Brueggemann M, Shine W, Prior L, Rohrer P, Taylor S, Rubenstein J, Gilley K, Malcolm K, Mullins E, Saperia G, Arsenault P, Berni-Giarusso K, Granger C, McMurtry M, Parrish J, Siegel C, Williams S, Hassett MA, Long T, Zidar J, Morris K, Kennelly B, McReynolds L, Eslami B, Nanette-Silvius VE, Wood F, Adams V, Nirula A, Bisnar A, Kern L, Williams S, Moran M, Williams J, Brodsky M, Ahmadi-Kashani M, Eslami B, Lamon S, Eagle K, Kline-Rogers E, Yarows S, Chaivre P, Crawford I, Bhatia S, Caines S, Hubbard B, Smith MJ, Crandell M, Cannon C, Walsh E, Mamuya W, De Vellis P, Urbach D, Bull T, Horrigan M, Brown L, Juergens C, Newland E, Coverdale S, Murray S, Courtney M, Steward S, Fitzpatrick A, Aroney C, Walters D, Cleave P, Grant D, Pincus R, Brown M, Yudkin D, Smyth T, Boxall J, Cummins N, Gaul G, Poradek T, Lenz K, Firlinger F, Pichler M, Schernthaner C, Zenker G, Doppler R, Kiss H, Strohmaier E, Islam N, Saraiva JF, Corte C, Medeiros SM, Correa da Silva JA, Mesquita ET, Bernardez S, Lima V, Araujo-Herkenhoff P, Passabom M, Ferreira CB, Gaui E, Markman-Filho B, Levy-Temporal S, Gun C, DeLuca F, DeLuca S, Grigorov M, Todorov G, Donova T, Stoikov A, Staykov I, Milanov S, Todorov T, Bolgurova M, Kozareva M, Andreev N, Raev D, Hergeldjieva V, Kamenova P, Ramshev K, Anev E, Benov H, Popov A, Vasilev I, Petranov S, Kazmin I, Gotcheva N, Georgiev B, Vladimirov T, Stoykova A, Vladimir V, Denchev S, Dimitrov S, Pelov R, Nachev C, Taseva T, Jorgova J, Trendafilova D, Kichukov N, Atanasov N, Penkov N, Georgiev S, Perchev I, Pesant Y, Sardin V, Rousseau S, Brossoit R, Belanger F, Bisson D, Naud M, Peck C, Houde G, Rousseau S, Dube S, Audet R, Allard A, Allard GM, Wellemans V, Harnarine C, Pasma J, Son K, Beveridge J, Carr T, DeYoung S, Vandeveide J, Mansour S, le Lemay C, DeYoung JP, Watt M, Hilton D, Johnston M, Paillard C, Rose B, Rideout MA, Diodati J, Groulx C, Constance C, Gauthier MF, Burrows M, Watt M, Lamothe M, Sevigny JL, Grondin F, Bilodeau N, Dumont F, Fournier R, Ouellet G, Picard JP, Marquis J, Picard N, Polasek P, Husch J, Mantle M, Morrison S, Schenk E, Stedham V, Dery JP, Bertrand O, Keilani S, Lariviere MM, Imrie J, McGregor J, Chauret D, Argibay-Poliquin E, Marquis M, Huynh T, Boudreault C, Branco N, Giguere C, Rubinowicz A, Serpa A, Sullivan L, Gallo R, Gendron N, Theroux P, Tarhuni W, Ireland D, Mrabet R, Lai K, Cameron A, Hannah G, Johnston D, Robinson A, Vennard J, Mallette D, Zaniol D, Pallie S, Krekorian S, Ashton T, Giannoccaro P, Beresford P, Zimmermann R, Altwasser C, Patterson G, Orenstein T, Berda P, Wagner S, Ervin F, Duamel G, Yarkayeva Z, Halperin F, Mukherjee A, Bozek B, Simkus G, Marchand C, Haichin R, Toyota V, Paddock V, Collings E, Fitzgerald F, Heath K, Ramanathan K, Minhas S, Hajek P, Miklosova L, Zwanenburg E, Kornder J, Elliott H, Perry M, Shaw V, Baer C, MacLoughlin C, Steeves R, Cherry J, Ross B, Smith J, Lai C, Fox G, Saarinen T, Stolz C, Gyenes G, Flathers J, Harris L, Wong G, Gamache J, Tarry L, Sobkowski W, Lu S, Chen Y, Chen J, Zhang J, Li WM, Geng J, Han W, Li GL, Yam H, Zhou G, Zhou Y, Luo J, Zhang Y, Du Z, Yang H, Li G, Luo C, Cao K, Wu X, Jia M, Huang Z, Wu S, Yan Y, Yan X, Guan W, Li H, Qi L, Huo Y, Jiang J, Zhang Y, Zhang M, Li G, Jeng R, Wu G, Ge J, Wang W, Escobar A, Marmol A, Matias N, Isaza D, Montanez Z, Gomez E, Granados P, Izurieta H, Basagoitia AM, Hesse P, Barkhausen H, Loewis P, Noeldeke H, Unverdorben M, Degenhardt R, Lawall H, Menges A, Meier T, Tebbe U, Lengfelder W, Nega N, Zotz RJ, Wild P, Severin R, Claus G, Gaudron P, Kugler I, Keller H, Stiepak C, Mueller M, Konermann M, Rawert B, Scholz K, Moeller K, Hartmann H, Borkert C, Klaus A, Lüders S, Hausmann D, Grommas I, Ruef J, Rodas M, Montenegro P, Soto-Mora G, Moscato V, Moccia D, Tuccillo B, Sacra C, Grassi R, Di Tano G, Casazza F, Bongarzoni A, Greco C, Barbieri G, Casaccia M, Millesimo G, Brindicci G, Locuratolo N, Cuccia C, Assennato P, Farinella M, Zonzin P, Roncon L, Barbiero M, Gemelli M, Scabbia E, Ficili S, Lai C, Congiu R, Di Biase M, Mavilio G, Kalnins U, Erglis A, Maca A, Stradins P, Garcia-Castillo A, Maldonado B, Lupi E, Martinez C, Dominguez B, Diaz R, Pariona M, Maciejewicz J, Maziarz A, Janik K, Cichon D, Binio Z, Zablocka A, Ogorek M, Danuta K, Malinowski S, Monies F, Burduk P, Rozwodowska M, Piepiorka M, Surwilo J, Reszka Z, Mickiewicz-Pawlowska M, Quininha J, Ferreira R, Dorobantu M, Tatu-Chitoiu G, Macarie C, Qeshta D, Datcu M, Iliescu D, Amosova K, Prudkiy I, Parkhomenko A, Lutay Y, Dykun Y, Litvin E, Almahmeed W, Maqsood I, Teichholz L, Vargas G, DeFehr S, Little Sun E, Gorecki D, Vermilye M, D'Amico C, Tran H, Parrott C, Dunne T, Ferguson S, Glass S, Quale C, Shaw P, Videau B, Adams T, Carlson T, Crouch S, Foreman R, Martin D, Michael C, Khadra S, Drell MJ, Diez J, Szeplakay S, Diercks D, Gorhe A, Hiriart JC, Kuster F, Finizola B, Arai K, Alvarez M, Dalas P, D'Empaire G, Carrillo E, Ariaz C, Vergara G, Gonzalez F, Romero E, Vegas-Nunez A.

Author information

  • 1Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St. Michael's Hospital, University of Toronto, 30 Bond St, Room 6-034 Queen, Toronto, Ontario M5B 1W8, Canada. goodmans@smh.toronto.on.ca

Abstract

BACKGROUND:

The Global Registry of Acute Coronary Events (GRACE)-a prospective, multinational study of patients hospitalized with acute coronary syndromes (ACSs)-was designed to improve the quality of care for patients with an ACS. Expanded GRACE aims to test the feasibility of a simplified data collection tool and provision of quarterly feedback to index individual hospital management practices to an international reference cohort.

METHODS:

We describe the objectives; study design; study and data management; and the characteristics, management, and hospital outcomes of patients > or =18 years old enrolled with a presumptive diagnosis of ACS.

RESULTS:

From 2001 to 2007, 31,982 patients were enrolled at 184 hospitals in 25 countries; 30% were diagnosed with ST-segment elevation myocardial infarction, 31% with non-ST-segment myocardial infarction, 26% with unstable angina, and 12% with another cardiac/noncardiac final diagnosis. The median age was 65 (interquartile range 55-75) years; 24% were >75 years old, and 33% were women. In general, increases were observed over time across the spectrum of ACS (1) in the use in the first 24 hours and at discharge of aspirin, clopidogrel, beta-blockers, and angiotensin-converting enzyme inhibitors/receptor blockers; (2) in the use at discharge of statins; (3) in the early use of glycoprotein IIb/IIIa inhibitors and low-molecular-weight heparin; and (4) in the use of cardiac catheterization and percutaneous coronary intervention. An increase in the use of primary percutaneous coronary intervention and a similar decrease in the use of fibrinolysis in ST-segment elevation myocardial infarction were also seen.

CONCLUSIONS:

Over the course of 7 years, general increases in the use of evidence-based therapies for ACS patients were observed in the expanded GRACE.

PMID:
19619694
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk