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Cell Host Microbe. 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006.

Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

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  • 1Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

PMID:
19616761
[PubMed - indexed for MEDLINE]
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