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Transfus Apher Sci. 2009 Aug;41(1):13-7. doi: 10.1016/j.transci.2009.05.002. Epub 2009 Jul 16.

Impact of allogeneic 2-RBC apheresis on iron stores of Brazilian blood donors.

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  • 1Fundação Pró-Sangue/Hemocentro de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, Cerqueira Cesar, 05403-000 São Paulo, SP, Brazil. alfredo.mendrone@usp.br


One limiting factor for automated two-red blood cells collections (2-RBC) is its potential iron depletion. We analyzed hematological parameters and iron balance before, two and four months after 2-RBC of 96 non-supplemented male donors. Four months after 2-RBC, ferritin level was significantly lower (P<0.01) than baseline levels and the number of donors who presented ferritin <30 ng/ml increased from 18 to 47. We concluded that four months was not sufficient for iron recuperation in the population studied. In an attempt to avoid iron depletion after 2-RBC, we recommend augmentation in the interval between blood donations and pre-donation ferritin measurement.

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